1g IV q24h
Targeted therapy of ESBL infections and other resistant gram negative infections.
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.
Immediate and delayed-type allergy
Cytopenias, eosinophilia, positive Coombs
Liver enzyme abnormalities
Seizure risk lower than other carbapenems
Carbapenems may cause rapid and profound decrease in valproic acid levels. Increasing valproic acid dosage is often NOT sufficient to overcome this interaction. Avoid this combination if at all possible.
- NS only (incompatible with D5W).
- Dilute in 50mL NS, infuse over 30 min.
EH Prescribing Restrictions
- Pharmacist review of therapy
Community IV Formulary (Metro Region)
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 4 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Moderate