Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$1.57/day

Dosing

May be dosed without regard to dialysis schedule

Poorly dialyzed so no supplemental doses required in hemodialysis

No dosage adjustment required in renal dysfunction

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

General Information

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  •  Nosocomial gram negative infections (except Pseudomonas)

  •  Spontaneous bacterial peritonitis

  •  Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Additional Information

Use 2 g IV q12 h dose for meningitis or other CNS infection

IV Administration

  • Dilute in 50-100 mL D5W or NS and administer over 15-30 min.

  • Incompatible with Ringers Lactate or calcium-containing solutions

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic