Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$1.57/day

Dosing

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

May be dosed without regard to dialysis schedule

Poorly dialyzed so no supplemental doses required in hemodialysis

No dosage adjustment required in renal dysfunction

General Information

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  •  Nosocomial gram negative infections (except Pseudomonas)

  •  Spontaneous bacterial peritonitis

  •  Hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Additional Information

Use 2 g IV q12 h dose for meningitis or other CNS infection

IV Administration
- Dilute in 50-100 mL D5W or NS and administer over 15-30 min.
- Incompatible with Ringers Lactate or calcium-containing solutions

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Urine penetration: Therapeutic

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic