Good (70 to 90%)
300-450mg IV q8h
Necrotizing SSTI or toxic shock syndrome
900mg IV q8h
300-450mg PO q6-8h
No dosage adjustment required in renal dysfunction
No supplemental doses required for Intermittent HD patients
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
None specific. Monitor for diarrhea.
Muscle relaxants, e.g., atracurium, baclofen, diazepam.
St. Johns Wort
OPEN BENEFIT (PO)
No prescribing restrictions
Doses up to 900 mg: dilute in 100 mL D5W or NS and administer over 30 min.
EH Prescribing Restrictions
Community IV Formulary (Metro Area)
Capsules can be opened and administered via NG route; Liquid formulation also available
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor