For C. difficile diarrhea only
PO vancomycin is not absorbed through intact GI tract membranes and should NEVER be used to treat systemic infection.
125mg po/ng/og q6h for 10-14 days.
For Fulminant CDAD
- 500 mg PO/NG QID
- ID consult recommended
- If ileus present
- 500 mg in 100mL of NS by rectal enema q6h
Treatment of LOCALIZED infections of the GI tract (i.e. CDAD)
See Eastern Health Treatment Guidelines for details
Any systemic infection (i.e anything outside the GI tract)
Vancomycin absorption is minimal when given orally
PO vancomycin should never be used to treat systemic infection and is not appropriate alternative if iv access is lost.
Only indication is in the therapy of C. difficile infection
Possibility of accumulation in severe renal dysfunction.
OPEN BENEFIT (PO)
No prescribing restrictions
EH Prescribing Restrictions
None (Pharmacist reviews therapy)
Powder from vancomycin capsules will clog NG tubes. If need to administer via tube, reconstitute vial with appropriate diluent and give via NG route.
Antimicrobial class: Glycopeptide
Pregnancy category: B
Average serum half life: 0 hours
Biliary penetration: None
CSF penetration: None
Lung penetration: None
Urine penetration: None