6-10mg/kg IV daily
Skin and soft tissue infections
4mg/kg IV daily
Unknown for severe hepatic dysfunction
Targeted therapy of resistant gram positive infections when use of first line agents precluded by allergy or intolerance
Creatine kinase and creatinine at least weekly
(more frequently if renal function changing or unstable)
GI side effects common
Myopathy including rhabdomyolysis
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
- Dilute in 100 mL NS and administer over 30 min.
- Concentration range: 2.5-20 mg/mL
EH Prescribing Restrictions
- Pharmacist review (with ID consult if required)
- See Systemic Antimicrobial Formulary Policy (PHA-305) for full details
Community IV Formulary (Metro Area)
Inactivated by pulmonary surfactant : Not indicated for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide.
Pregnancy category: B
Average serum half life: 9 hours
Urine penetration: Therapeutic
Lung penetration: Poor
CSF penetration: Poor