Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$12.16/day

Dosing

3.375-4.5g IV q6h

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  •  Pneumonia

  •  Intra-abdominal/hepatobiliary

  •  UTI

  •  Polymicrobial skin and soft tissue infection

  •  Febrile neutropenia

Drug Monitoring

Patients on therapy for > 7 days should have (at least) weekly CBC due to risk of drug-induced neutropenia and thrombocytpoenia

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Additional Information

IV Administration
Dilute in 100 mL D5W or NS and administer over 30-60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic