Ceftazidime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$14.88/day

Dosing

1-2g IV q8h

General Information

Common Usage

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins

Adverse Effects

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Additional Information

IV Administration
Dilute in 50-100 mL D5W or NS and administer over 15-30 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic