Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate (40 to 70%)

Approximate Cost

$1.08 (PO)
$15.00 (IV)

Spectrum Of Activity

Dosing

2g IV q4-6h

500-1000 mg PO q6h

No dosage adjustment required for renal dysfunction

General Information

Common Usage

Treatment of MSSA infections

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tablet/Capsule Strengths

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

IV Administration
Dilute in 100 mL D5W or NS and administer over 30-60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Capsules can be opened and administered via NG route; Liquid also available

Administration on empty stomach increases absorption but increases GI intolerance

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic