Antimicrobials
Cloxacillin

Cloxacillin

Medium
Moderate (40 to 70%)
$1.08 (PO) $15.00 (IV)

Spectrum of Activity

Dosing

General Information

Treatment of MSSA infections

  • Allergy (immediate or delayed)
  • Cytopenias
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • Phlebitis at injection site in a peripheral vein
  • Can increase methotrexate levels
  • Decrease mycophenolate levels

IV Administration: Dilute in 100 mL D5W or NS and administer over 30-60 min.

Capsules can be opened and administered via NG route; Liquid also available.

Administration on empty stomach increases absorption but increases GI intolerance.

OPEN BENEFIT (PO): No prescribing restrictions

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic