Candida infections both mucocutaneous and invasive - i.e. Candidemia.
Cryptococcus and Coccidioides infections.
Antifungal prophylaxis in immunocompromised.
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.
Hepatic enzyme abnormalities
Many via CYP450. Suggest review specific patient medications.
Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.
Risk when combining with other QTc prolonging medications.
OPEN BENEFIT (PO)
50 and 100 mg tablets - no prescribing restrictions
150 mg single dose formulation for vaginal candidiasis not covered
Premixed bags of 200 and 400 mg; infuse over 1 hr (200 mg) or 2 hrs (400 mg)
Premixed bags are not compatible with pumps used in Community IV program
EH Prescribing Restrictions
Community IV Formulary (Metro Area)
Tablets may be crushed for NG administration; Liquid formulation also available
Antimicrobial class: Triazole antifungal
Pregnancy category: C
Average serum half life: 20 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Therapeutic