Tobramycin is not indicated for synergy in Gram positive infections
Serum creatinine whenever initiating any aminoglycoside.
Creatinine and trough level should be monitored AT LEAST twice weekly; more often if unstable renal function or addition of nephrotoxic medications.
Order appropriate trough level for dosage regimen used
Tobramycin Peaks
Nephrotoxicity
Vestibulocochlear toxicity
Other
Increased nephrotoxicity
Increased ototoxicity
Neuromuscular blockade agents - Respiratory paralysis.
IV Administration: Dilute in 100 mL D5W or NS and administer over 30-60 min. (*60 min for extended interval dosing)
IV: N/A
Nebules: generic are open benefit
TOBI brand require Special Authorization (CF)
Antimicrobial class: Aminoglycoside
Pregnancy category: D
Average serum half life: 3 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Moderate
Route of Elimination: Renal