Antimicrobials
Levofloxacin

Levofloxacin

High
Excellent (90 to 100%)
$0.30 (PO) $81.87 (IV)

Dosing

General Information

  • Lower respiratory infection (CAP, HAP)
  • Intraabdominal infection (with metronidazole)

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis
  • Other QTc prolonging agents
  • Divalent cations - Decreased absorption
  • NSAIDs - Increase seizure risk
  • Warfarin - Increased INR

IV Administration: Premixed bags; infusion time 250 mg (30 min), 500 mg (60 min), 750 mg (90 min)

NLPDP Status (PO): Special Authorization required

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic