C difficile risk
Oral Bioavailability
Excellent (90 to 100%)
$0.12 (PO)


100mg PO BID

Hemodialysis, Peritoneal DialysisNo dose adjustment necessary.

No supplemental doses required after hemodialysis.

General Information

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Methicillin resistant staphylococcus aureus (MRSA)infections

  • Sterile site S. aureus isolates such as blood should not be treated with doxycycline

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

PO absorption of doxycycline is excellent. This route should be used in most cases.

EH Prescribing Restrictions

  • PO: None

  • IV doxycycline is available via Health Canada Special Access Program only.

  • For special access drug availability contact SAP program ((613) 941-2108 OR [email protected]) or your Pharmacy department.

  • No liquid formulation available

  • Capsules can be opened and given via NG route

No prescribing restrictions

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic