Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent (90 to 100%)

Approximate Cost

$0.12 (PO)

Dosing

Hemodialysis, Peritoneal DialysisNo dose adjustment necessary.

No supplemental doses required after hemodialysis.

100mg PO BID

General Information

Common Usage

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Methicillin resistant staphylococcus aureus (MRSA)infections

  • Sterile site S. aureus isolates such as blood should not be treated with doxycycline

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

Major Interactions

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Tablet/Capsule Strengths

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

PO absorption of doxycycline is excellent. This route should be used in most cases.

EH Prescribing Restrictions

  • PO: None

  • IV doxycycline is available via Health Canada Special Access Program only.

  • For special access drug availability contact SAP program ((613) 941-2108 OR sapdrugs@hc-sc.gc.ca) or your Pharmacy department.

  • No liquid formulation available

  • Capsules can be opened and given via NG route

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic