Excellent (90 to 100%)
Hemodialysis, Peritoneal DialysisNo dose adjustment necessary.
No supplemental doses required after hemodialysis.
100mg PO BID
Skin and soft tissue infection
Community acquired pneumonia
Methicillin resistant staphylococcus aureus (MRSA)infections
Sterile site S. aureus isolates such as blood should not be treated with doxycycline
GI upset and erosive esophagitis
Divalent cations - decreased absorption
Increased digoxin levels
Increased INR with warfarin
Some anticonvulsants can decrease doxycycline levels
OPEN BENEFIT (PO)
No prescribing restrictions
PO absorption of doxycycline is excellent. This route should be used in most cases.
EH Prescribing Restrictions
IV doxycycline is available via Health Canada Special Access Program only.
For special access drug availability contact SAP program ((613) 941-2108 OR email@example.com) or your Pharmacy department.
No liquid formulation available
Capsules can be opened and given via NG route
Antimicrobial class: Tetracycline
Pregnancy category: D
Average serum half life: 18 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic