Low (20 to 40%)
400mg PO BID
Prophylaxis of spontaneous bacterial peritonitis.
Monitor QTc in patients with increased risk
Tendinopathy and rupture
Weakness exacerbation in myasthenia gravis
CNS toxicity including confusion, psychosis
Other QTc prolonging agents.
Divalent cations - Decreased absoprtion.
Methadone - Increased seizures.
Warfarin - Increased INR.
OPEN BENEFIT (PO)
No prescribing restrictions
EH prescribing restrictions:
Tablets can be crushed for NG administration; No liquid formulation available
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Urine penetration: Therapeutic