Norfloxacin

C. diff Risk

High

Oral Bioavailability

Low (20 to 40%)

Approximate Cost

$1.20/day

Dosing

400mg PO BID

General Information

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Warfarin - Increased INR.

Tablet/Capsule Strengths

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

EH prescribing restrictions:
None

Tablets can be crushed for NG administration; No liquid formulation available

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic