Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia when first line therapies are precluded by allergy, organism resistance or intolerance/adverse drug reaction.
Covers MRSA and VRE.
CBC at least once/week
Visual testing for therapy >3 months or if symptoms develop on therapy.
Elevated liver enzymes
Myelosuppression (usually with >2weeks therapy)- reversible
Peripheral/optic neuropathy with prolonged courses
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Pharmacist consult recommended to review drug interactions.
Rifampin decreases linezolid levels.
Special Authorization Required
EH Prescribing Restrictions:
Pharmacist review (with ID consult if required)
See Systemic Antimicrobial Formulary Policy (PHA-305)) for full details.
NLPDP Status (PO):
Special Authorization required
Costs for PO are based on Eastern Health Contract Pricing.
Costs are MARKEDLY higher (i.e. > $1000 for a 10 day course) in Community Setting.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic