600mg PO/IV q12h
600 mg PO/IV q12h
No dose adjustment required in renal dysfunction including dialysis
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia when first line therapies are precluded by allergy, organism resistance or intolerance/adverse drug reaction.
Covers MRSA and VRE.
CBC at least once/week
Visual testing for therapy >3 months or if symptoms develop on therapy.
Elevated liver enzymes
Myelosuppression (usually with >2weeks therapy)- reversible
Peripheral/optic neuropathy with prolonged courses
Special Authorization Required
- 600 mg premixed bags; infuse over 60 min
- Premixed bags are not compatible with pumps used by Community IV Program
EH Prescribing Restrictions:
Pharmacist review (with ID consult if required)
See Systemic Antimicrobial Formulary Policy (PHA-305)) for full details.
NLPDP Status (PO):
Special Authorization required
Costs for PO are based on Eastern Health Contract Pricing.
Costs are MARKEDLY higher (i.e. > $1000 for a 10 day course) in Community Setting.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic