Antimicrobials
Voriconazole

Voriconazole

Low
Excellent (90 to 100%)
$4.04 (PO) $124.00 (IV)

Spectrum of Activity

Dosing

General Information

  • Candida infections both mucocutaneous and invasive - i.e. Candidemia.
  • Antifungal prophylaxis in immunocompromised patients.
  • Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (Discuss with ID).
  • Check with chemistry lab as specimen may need to be referred out of province.
  • QTc interval in patients at elevated risk.
  • Monitor hepatic profile.
  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • Visual disturbance
  • Fluorosis
  • GI upset
  • CYP450 interactions ++.
  • Other QTc prolonging agents.
  • Recommend review of pt medications due to high frequency of significant interactions.

IV Administration

  • Dilute in 100-250 mL D5W or NS and administer over 1-2 hrs
  • Max concentration 5 mg/mL
  • Max rate 3 mg/kg/min

NLPDP Status: Requires Special Authorization

Note

  • Costs for PO are based on Eastern Health Contract Pricing
  • Costs are MARKEDLY higher in Community Setting

Antimicrobial class: Triazole antifungal, Second generation

Pregnancy category: D

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor