Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Good (70 to 90%)

Approximate Cost

$ 0.87/day

Dosing

500mg PO TID of the amoxicillin component

Alternate Option
- 875 mg PO BID
- 875 mg tabs may be difficult to swallow

General Information

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

For prolonged therapy, monitor liver enzymes and function.

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Major Interactions

Increased risk of rash with allopurinol

Tablet/Capsule Strengths

  • Open Benefit
  • No prescribing restrictions

Additional Information

EH Prescribing Restrictions
None

Tablets can be crushed and given via NG tube; Liquid also available

Bioavailability classification based on Amoxicillin component

Clavulanic acid bioavailability varies from 30-98%

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

Urine penetration: Therapeutic