Good (70 to 90%)
500mg PO TID of the amoxicillin component
- 875 mg PO BID
- 875 mg tabs may be difficult to swallow
Prophylaxis/treatment of bite wounds.
Polymicrobial infections of the respiratory tract or abdomen.
Skin and soft tissue infections.
For prolonged therapy, monitor liver enzymes and function.
Allergy/rash (immediate or delayed)
Note EBV related rash
Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.
Increased risk of rash with allopurinol
EH Prescribing Restrictions
Tablets can be crushed and given via NG tube; Liquid also available
Bioavailability classification based on Amoxicillin component
Clavulanic acid bioavailability varies from 30-98%
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
Urine penetration: Therapeutic