Spectrum Of Activity
(e.g. CNS and Disseminated Zoster)
10mg/kg IV q8h
800mg PO 5 times per day
Prophylaxis dosing varies by indication
eGFR 0 - 10eGFR 10 - 25eGFR 25 - 50eGFR > 505mg/kg IV q24h, or half of regular dose q24h10mg/kg IV q24h10mg/kg IV q12h10mg/kg IV q8h (Regular dosing)
2.5-5mg/kg IV q24h
Give dose after dialysis on dialysis days
Peritoneal Dialysis 5-10 mg/kg IV q24h5mg/kg IV q24h, or half of regular dose q24h
Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate.
Check urine for crystals if AKI suspected.
AKI from crystal nephropathy
Mycophenolate can increase the acyclovir concentration.
May diminish efficacy of zoster or varicella vaccine.
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Give over at least 60 min in D5W or NS; maximum concentration 10 mg/mL
EH Prescribing Restrictions
Community IV Formulary (Metro Area)
OPEN BENEFIT (PO)
No prescribing restrictions
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic
Urine penetration: Therapeutic