Poor (Less than 20%)
(e.g. CNS and Disseminated Zoster)
10mg/kg IV q8h
800mg PO 5 times per day
Prophylaxis dosing varies by indication
Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate.
Check urine for crystals if AKI suspected.
AKI from crystal nephropathy
Mycophenolate can increase the acyclovir concentration.
May diminish efficacy of zoster or varicella vaccine.
OPEN BENEFIT (PO)
No prescribing restrictions
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Give over at least 60 min in D5W or NS; maximum concentration 10 mg/mL
EH Prescribing Restrictions
Community IV Formulary (Metro Area)
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic
Urine penetration: Therapeutic