Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Good (70 to 90%)

Approximate Cost

$0.15/day

Spectrum Of Activity

Dosing

500-1000mg po TID

eGFR 0 - 10eGFR 10 - 50eGFR > 50500mg PO q24h500mg PO q8-12h500-1000mg PO q8h

500-1000mg po q24h

Take after dialysis on HD days

General Information

Common Usage

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

Major Interactions

Allopurinol - increased rash

Additional Information

EH Prescribing Restrictions
None

Capsules may be opened and administered via NG tube; Liquid also available

NLPDP Status

OPEN BENEFIT
No prescribing restrictions

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic