Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$3.81/day

Dosing

2 gm IV q8h (max 6 gm/day)

General Information

Common Usage

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Probenecid is available only for use in management of UNCOMPLICATED Skin and soft tissue infections for Community IV patients. Patients admitted to hospital while receiving cefazolin/probenecid as outpatients should be converted to cefazolin alone based on their renal function.

Probenecid has no place in the therapy of inpatients and requests for this indication will not be approved.

Additional Information

IV Administration
Dilute in 50-100 mL D5W or NS and administer over 30-60 min.

EH Prescribing Restrictions
None

Community IV Formulary (St. John's Metro)
YES

Staphylococcal isolates reported as cloxacillin-suscpetible (i.e. MSSA) are also susceptible to cefazolin.

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic