Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate (40 to 70%)

Approximate Cost

$1.78/day (PO)
$13.05 /day (IV)

Dosing

750-1500mg IV q8h

250-500mg PO q12h

General Information

Common Usage

  •  Community acquired pneumonia with a macrolide

  •  Intraabdominal infection

  •  Epiglottitis

Adverse Effects

  •  Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  GI upset

  •  Diarrhea

  •  Abnormal liver enzymes

Major Interactions

No significant interactions.

Tablet/Capsule Strengths

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

IV Administration
Dilute in 50-100 mL D5W or NS and administer over 30-60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Tablets can be crushed and given via NG route; Liquid formulation also available

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic