Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$55.49

Spectrum Of Activity

Dosing

Severe Impairment (Child-Pugh Class C)The manufacturer provides no dosing guideline. Not studied.

Moderate Impairment (Child-Pugh Class B)70 mg IV once then 35 mg IV daily

Mild Impairment (Child-Pugh Class A)No adjustment required

No dose adjustment required.

Poorly dialyzed, no supplemental doses required in hemodialysis.

General Information

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

- Increased liver enzymes
- GI upset

Major Interactions

  • Decreases levels of Tacrolimus

  • Cyclosporine may increase levels of Caspofungin

  • Rifampin may decrease Caspofungin concentrations

Additional Information

IV Administration

  • NS only (incompatible with D5W).

  • Dilute in 250 mL NS, infuse over 60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor