Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$55.49

Dosing

The manufacturer provides no dosing guideline. Not studied.
Severe Impairment (Child-Pugh Class C)

70 mg IV once then 35 mg IV daily
Moderate Impairment (Child-Pugh Class B)

No adjustment required
Mild Impairment (Child-Pugh Class A)

No dose adjustment required.

Poorly dialyzed, no supplemental doses required in hemodialysis.

General Information

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

- Increased liver enzymes
- GI upset

Major Interactions

  • Decreases levels of Tacrolimus
  • Cyclosporine may increase levels of Caspofungin
  • Rifampin may decrease Caspofungin concentrations

Additional Information

IV Administration
- NS only (incompatible with D5W).
- Dilute in 250 mL NS, infuse over 60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Poor

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor