Low (20 to 40%)
500 mg PO QID
IV: 500 mg to 1 g every 6 hours; maximum: 4 g daily
No dosage adjustment necessary for renal dysfunction.
Supplemental dose is not necessary in hemo- or peritoneal dialysis or in CRRT
Erythromycin is a major inhibitor of CYP3A4. Consult a drug interactions database for more detailed information.
Other drugs that prolong QTc
Increases cyclosporine levels
Statins increased risk of rhabdomyolysis
Increases INR with warfarin
OPEN BENEFIT (PO)
No prescribing restrictions
NS only (incompatible with D5W).
Dilute in 100-250 mL NS, infuse over 30-60 min. Max concentration 5 mg/mL.
EH Prescribing Restrictions
Community IV Formulary (Metro Area)