Erythromycin

C. diff Risk

None

Oral Bioavailability

Low (20 to 40%)

Approximate Cost

$0.80 (PO)
$114.80 (IV)

Dosing

500 mg PO QID

IV: 500 mg to 1 g every 6 hours; maximum: 4 g daily

No dosage adjustment necessary for renal dysfunction.

Supplemental dose is not necessary in hemo- or peritoneal dialysis or in CRRT

General Information

Major Interactions

  • Erythromycin is a major inhibitor of CYP3A4. Consult a drug interactions database for more detailed information.
  • Other drugs that prolong QTc
  • Increases cyclosporine levels
  • Statins increased risk of rhabdomyolysis
  • Increases INR with warfarin

Tablet/Capsule Strengths

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

IV Administration
- NS only (incompatible with D5W).
- Dilute in 100-250 mL NS, infuse over 30-60 min. Max concentration 5 mg/mL.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
NO