Erythromycin

C difficile risk
None
Oral Bioavailability
Low (20 to 40%)
Cost
$0.80 (PO) $114.80 (IV)

Dosing

500 mg PO QID

IV: 500 mg to 1 g every 6 hours; maximum: 4 g daily

No dosage adjustment necessary for renal dysfunction.

Supplemental dose is not necessary in hemo- or peritoneal dialysis or in CRRT

General Information

  • Erythromycin is a major inhibitor of CYP3A4. Consult a drug interactions database for more detailed information.

  • Other drugs that prolong QTc

  • Increases cyclosporine levels

  • Statins increased risk of rhabdomyolysis

  • Increases INR with warfarin

IV Administration

  • NS only (incompatible with D5W).

  • Dilute in 100-250 mL NS, infuse over 30-60 min. Max concentration 5 mg/mL.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
NO

OPEN BENEFIT (PO)
No prescribing restrictions