Antimicrobials
Rifampin

Rifampin

N/A
Good (70 to 90%)
$0.99 (PO) $48.99 (IV)

Spectrum of Activity

Dosing

General Information

Synergistic therapy of gram positive organisms in some cases (i.e. prosthetic valve endocarditis)

Monotherapy of any infection (use as single-agent prophylaxis in N. meningitidis outbreak settings is acceptable)

  • Mycobacterial infections
  • Brucellosis
  • Osteomyelitis
  • Prosthetic joint infections due to Staphyloccocus aureus (always use in combination with other agents).

Lab

  • Baseline and periodic LFTs

Clinical

  • Multiple drug interactions
  • Nausea/vomiting, diarrhea
  • Abnormal liver enzymes
  • Rash (Steven-Johnson syndrome)
  • Myopathy
  • Inducer of many CYP enzymes including 3A4, and 2C9.
  • Anticoagulants and anticonvulsants are among those affected but list of interacting drugs is large.
  • A Pharmacy consult is recommended when initiating rifampin therapy.

Capsules may be opened and given via NG route

Suspension is available but has to be made by Pharmacy Department

For special access drug availability contact:

OPEN BENEFIT (PO): No prescribing restrictions

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces