Synergistic therapy of gram positive organisms in some cases (i.e. prosthetic valve endocarditis)
Monotherapy of any infection (use as single-agent prophylaxis in N. meningitidis outbreak settings is acceptable)
Prosthetic joint infections due to Staphyloccocus aureus (always use in combination with other agents).
Abnormal liver enzymes
Rash (Steven-Johnson syndrome)
Inducer of many CYP enzymes including 3A4, and 2C9.
Anticoagulants and anticonvulsants are among those affected but list of interacting drugs is large.
A Pharmacy consult is recommended when initiating rifampin therapy.
OPEN BENEFIT (PO)
No prescribing restrictions
Capsules may be opened and given via NG route
Suspension is available but has to be made by Pharmacy Department
EH Prescribing Restrictions
(IV): Use restricted via Special Access Program
For special access drug availability contact:
SAP program (613-941-2108 OR
Your Pharmacy department.
Eastern Health provides rifampin prophylaxis during meningococcal outbreak free of charge as per policy 440-PHA-DDD-176
Prescription Processing and Dispensing (Outpatients)
The Pharmacy Department provides services to the Department of Health (Communicable Disease) as and when required, for the provision of medication required in the prevention of diseases such as Meningococcal outbreak, etc.
During regular working hours (1030 to 1600), this service may be accessed by calling the Pharmacy Department at 777-6244(5). After hours, the main Health Sciences Centre hospital pharmacy or Pharmacist-on-call may be contacted for emergency only.
All costs incurred in the completion of such requests are directed to the Department of Health.
Antimicrobial class: Antimycobacterial
Pregnancy category: C
Average serum half life: 3-4 hr
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Route of Elimination: Feces