Anaerobic spore forming Gram positive bacilli, box-car shaped
Nosocomial more common than community onset diarrhea, usually after taking antibiotics.
Can occur in outbreaks.
Recurrence is very common, therefore previous history of C. difficile is a risk factor.
Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.
Profuse, watery diarrhea
Pseudomembranous colitis or toxic megacolon.
Fecal microbiota transplantation is effective and safe however this is not currently performed in Newfoundland and Labrador.