Clostridiodes difficile Diarrhea


Discontinue other antibiotics when possible

Discontinue treatments which create diarrhea

Discontinue proton-pump inhibitors when possible

Treat fulminant CDAD empirically, pending confirmation of the diagnosis


First test of stool is multiplex PCR.

If PCR detects C.difficile DNA, then toxin is tested.

If DNA is detected but toxin is not detected, the patient is colonized and does not require treatment for C.difficile.