Diabetic Foot Infections

Pathogenesis

Hyperglycemia, neuropathy, dry, cracked skin and peripheral vascular disease contribute to infection of skin ulcers, which leads to amputation and mortality.

Approximately 50% of diabetic foot ulcers are infected. Prognosis for healing is based on bacterial ecology (microbiome) and biofilm formation, which is not adequately described by conventional bacterial culture testing.