Emperic antibiotic therapy should be selected based on local resistance epidemiology, severity, previous culture and recent therapy.
Mild and moderate diabetic foot infections may be treated empirically with antibiotics targeting skin flora (Staphylococci and Streptococci) alone, unless ischemic or likely to be antibiotic resistant.
Severe diabetic foot infections should be treated empirically with antibiotics targeting skin and gut flora (Pseudomonas, anaerobes).
Topical antibiotic treatment should be not used alone for diabetic foot infections.
Targeted treatment is based on culture results. Use the narrowest spectrum possible.
Duration of treatment for soft tissue infection is until signs and symptoms of infection resolve, not until complete healing.
Duration of treatment for bone infection is 4-6 weeks, or until infection is surgically resected.