Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Dosing

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

General Information

Adverse Effects

  • Allergy and rash as for all beta-lactams

  • Cytopenias

  • Eosinophilia

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge.

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  • Nosocomial gram negative infections (except Pseudomonas)

  • Spontaneous bacterial peritonitis

  • Hospitalized community or nursing healthcare associated pneumonia in combination with a macrolide

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic