Cephalexin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Spectrum Of Activity

Dosing

500-1000mg PO QID

eGFR 0 - 10eGFR 10 - 50eGFR > 50500mg PO q12-24h500mg PO q12h500-1000mg PO q6h

500mg PO q12-24h

Dose after dialysis on hemodialysis days

General Information

Adverse Effects

  •  Allergy and rash as for all beta-lactams

  •  Positive Coombs

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

Common Usage

  •  Uncomplicated skin and soft tissue infection

  •  MSSA infections

Major Interactions

Increases metformin levels

Pharmacology

Antimicrobial class: First Generation Cephalosporin

Pregnancy category: B

Biliary penetration: Moderate

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic