Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Dosing

Cystitis
Macrobid 100mg PO BID

eGFR 0 - 50eGFR > 50ContraindicatedMacrobid 100mg po BID

Contraindicated

Contraindicated

General Information

Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Adverse Effects

  • Interstitial pneumonitis and fibrosis especially with prolonged use

  • Peripheral neuropathy

Common Usage

Uncomplicated cystitis in females with normal renal function.

Major Interactions

Antacids decrease absorption.

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic