Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Dosing

500-1000mg po TID

eGFR 0 - 10eGFR 10 - 50eGFR > 50500mg PO q24h500mg PO q8-12h500-1000mg PO q8h

500-1000mg po q24h

Take after dialysis on HD days

General Information

Adverse Effects

  •  Allergy and rash as for all beta-lactams

  •  Note EBV related rash

  •  Cytopenias

Common Usage

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.

Major Interactions

Allopurinol - increased rash

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic