Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

eGFR 0 - 10eGFR 10 - 50eGFR > 502g IV q12-24h2g IV q6-12h2g IV q6h

1-2g IV q12-24h

Dose after HD on dialysis days

Load 2g then 1-2g IV q6h

General Information

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Major Interactions

Increased risk of rash with allopurinol.

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic