Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

2 gm IV q8h (max 6 gm/day)

eGFR 0 - 10eGFR 10 - 40eGFR 40 - 60eGFR> 601-2g IV q24-48h1-2g IV q12h1-2g IV q8h2g IV q8h

1g IV daily given post-HD on dialysis days.

For serious infections consider 2g IV daily.

Other regimens exist.

1-2g IV q12h

General Information

Adverse Effects

Allergy and rash as for all beta-lactams.

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Common Usage

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic