Ampicillin-Sulbactam

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

1.5-3 g IV every 6 hr

CrCl > 50 mL/minCrCl 10 - 50 mL/minCrCl < 10mL/min (ESRD not on HD)3 g IV Q6h3 g IV Q8h3 g IV Q12h

3g IV Q12-24h

3g IV Q8-12h

General Information

Adverse Effects

  • Allergy/Skin rash

  • Diarrhea

  • Pain at injection site/phlebitis

Common Usage

  • Skin and soft tissue infections

  • Polymicrobial infections of the respiratory tract or abdomen

Drug Monitoring

Lab
In patients with preexisting hepatic impairment, periodic hepatic funtion monitoring

Clinical
Hypersensitivity reactions

Major Interactions

Allopurinol - Increased rash

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour