Consider alternative etiologies such as venous stasis or dependent rubor
Erythema associated with cellulitis should NOT resolve with elevation of the limb as opposed to chronic venous stasis
Resistance is increasing among previously susceptible organisms (Grp A & B Strep, MSSA & MRSA, anaerobes)
Very high risk for C. difficile infection
Only appropriate as synergistic agent in Grp A Strep necrotizing fascititis and toxic shock syndrome
Beta haemolytic Streptococci (i.e., Group A & B) are the predominant pathogens
Guideline originally sourced from Saskatchewan Health Authority - Saskatoon Area and adapted by Joseph Brant Hospital
Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America [published correction appears in Clin Infect Dis. 2015 May 1;60(9):1448. Dosage error in article text]. Clin Infect Dis. 2014;59(2):e10-e52.
Sinai Health System & UHN Antimicrobial Stewardship Program Management of Uncomplicated Skin and Skin Structure Infections: Non-Purulent Treatment Guidelines. (No Date). Accessed June 2020 from: www.antimicrobialstewardship.com/nonpurulentssi
The Johns Hopkins University (2020) John Hopkins ABX Guide (1.27) [Mobile App] Retrieved from: www.hopkinsguides.com
Antimicrobial Therapy Inc (2020) The Sanford Guide (4.2) [Mobile App] Retrieved from: www.sanfordguide.com/
Approved: June 2020
Revised: May 2022 (added cefadroxil for outpatients)