Antimicrobials
Linezolid

Linezolid

Restricted

Low
Complete (100%)
PO: 32.61$/day IV: 144.87$/day

Spectrum of Activity

Dosing

General Information

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.

Covers MRSA and VRE.

CBC at least once/week

Visual testing for therapy >3 months or if symptoms develop on therapy.

  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • Myelosuppression (usually with >2weeks therapy) - reversible
  • Peripheral/optic neuropathy with prolonged courses

SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.

Rifampin decreases linezolid levels.

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic