Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Dosing

MeningitisSerious Infection50 mg/kg/dose IV every 8 hr30 mg/kg/dose IV every 12 hr

MeningitisSerious Infection50 mg/kg/dose IV every 8 hr30 mg/kg/dose IV every 12 hr

Meningitis or Serious Infection50 mg/kg/dose IV every 8 hr
(max 2 grams/dose)

2 g every 8-12 hr

CrCl > 60 ml/minCrCl 30-60 ml/minCrCl 11-29 ml/minCrCl < 11 ml/minNo dose adjustment necessary 2 g IV every 12 hr2 g IV every 24 hr1 g IV every 24 hr

1 g IV every 24 hr

Dose post-HD on dialysis days

2 g IV every 12 hr

General Information

  • Allergy (immediate & delayed)

  • ¬†Positive Coombs

  • ¬†GI effects/Diarrhea

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Lab

  • monitor renal function

Clinical

  • Hypersensitivity

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate