C. diff Risk


Oral Bioavailability


Approximate Cost

Spectrum Of Activity


Loading dose for Candidemia
800 mg IV

Serious Infections
(e.g. Candidemia, CNS/Endophthalmitis, Coccidioidomycosis)
400-800 mg IV every 24 hr

Other indications
100-400 mg IV/PO every 24 hr

General Information

Common Usage

Candida infections both mucocutaneous and invasive - i.e. Candidemia.

Cryptococcus and Coccidioides infections.

Antifungal prophylaxis in immunocompromised.

Drug Monitoring


  • periodic SCr and LFTs


  • Consider QTc monitoring if concomitant drugs affecting the interval or risk factors

  • Hypersensitivity

  • GI effects

  • jaundice

Adverse Effects

  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

Major Interactions

Many via CYP450. Suggest review specific patient medications.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.


Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic