Documented Allergy to Beta-lactams/vancomycin and/or resistant to other antimicrobials and one of the following criteria met:
Treatment of Intra-abdominal infection
Treatment of skin and soft tissue infection
Treatment of polymicrobial infections (not Psuedomonas or Proteus)
Pneumonia, as unacceptably high failure rates have been reported (see black box warning)
Bacteremia, as documented safety concerns exist.
Infections caused by Pseudomonas and Proteus species
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Avoid or use with caution in patients with tetracycline reactions.
GI side effects very prominent with significant nausea and vomiting.
Tetracycline related adverse events: photosensitivity, acute pancreatitis.
Rash, abnormal liver enzymes.
Oral contraceptives less effective.
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic