C. diff Risk


Oral Bioavailability



2 g IV every 8 hr for severe infections

CrCl > 30 ml/minCrCl 10-30 ml/minCrCl <2 g IV every 8 hr1 g IV every 8 hr500 mg IV every 8 hr

1 g IV load then 500 mg IV every 12 hr

2 g IV every 12 hr

General Information

  • Patients with a PCN allergy when a cephalosporin option with low/no risk of cross-reactivity exists

Has no gram positive or anaerobic coverage

  •  Elevated liver enzymes

  •  Eosinophilia

  •  Phlebitis at injection site

  •  Rash/allergy

  • Phlebitis at injection site

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Nebulized form used in cystic fibrosis patients

Empiric therapy for febrile neutropenia when severe penicillin allergy exists. Should be used in combination with a gram positive agent.


  • SCr

  • Monitor liver enzymes


  • Hypersensitivity

  • Diarrhea

  • Phlebitis at injection site

No significant interactions.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic