Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Spectrum Of Activity

Dosing

250-500 mg PO every 6-8 hr

No dose adjustment provided in manufacturer's labeling. Use with caution, excretion is prolonged in renal impairment.

General Information

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Lab

  • Periodic CBC, SCr

Clinical

  • ┬áMonitor for allergy

No significant interactions

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic