Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

Serious Infection25 mg/kg/dose IV every 12 hr. On day of life 8: change to 25 mg/kg/dose IV every 8 hr

Serious Infection25 mg/kg/dose IV every 8 hr. On day of life 8: change to 50 mg/kg/dose IV every 8 hr

Serious Infection50 mg/kg/dose IV every 8 hr
(max 2 grams/dose)

1-2 g IV every 8 hr

CrCl > 35CrCl 10-34 ml/minCrCl < 10 ml/minNo dose adjustment necessary2 g IV every 12 hr2 g IV every 24 hr

1g IV daily given post-HD on dialysis days

For serious infections consider 2 g IV daily

Other regimens exist

2 g IV every 12 hr

General Information

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Skin and soft tissue infection (e.g. cellulitis)

Surgical prophylaxis

Susceptible Staphylococcal, Streptococcal and gram negative infections

Lab

  • CBC, CMP

Clinical

  • Hypersensitivity

  • GI effects

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic