Cefoxitin

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

Serious Infection40 mg/kg/dose IV every 6 hr
(max 2 grams/dose)

1-2 g IV every 6-8 hr

CrCl > 50 ml/minCrCl 30-50 ml/minCrCl 10-29 ml/minCrCl 5-9 ml/minCrCl <5 ml/minNo dose adjustment necessary2 g IV every 8 hr2 g IV every 12 hr1 g every 12 hr1 g IV every 24 hr

  • 2 g IV after each dialysis session, maintenance dose as above based on estimated CrCl

General Information

  • GI effects, diarrhea

  • Hypersensitivity reaction

  • Perioperative pophylaxis in patients undergoing uncontaminated GI surgery, abdominal or vaginal hysterectomy, or cesarean section

Lab

  • periodic SCr

Clinical

  • Hypersensitivity reaction

  • Diarrhea

  • INR (may enhace effects of warfarin)

  • May enhance nephrotoxic effects of aminoglycosides

  • enhances the anticoagulant effects of warfarin

Antimicrobial class: Cephalosporin (second generation)

Average serum half life: 1.4 hr

Biliary penetration: good

CSF penetration: poor

Lung penetration: good

Urine penetration: good

Route of Elimination: primarily urine