C difficile risk
Oral Bioavailability


  • Low dose: PO 40-50 mg/kg/DAY divided q8h

  • High dose: PO 80-90 mg/kg/DAY divided q8h. High dose can be divided q12h for otitis media.

Max 4 g/DAY

PO 20-30 mg/kg/DAY divided q12h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and Urinary tract infection

Allergy/rash (immediate or delayed), cytopenias.

EBV related rash (not allergy).

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates, full-term: 3.7 hours

  • Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)