Oral:
Intravenous: Use in place of piperacillin/tazobactam in the empiric treatment of the following community-acquired, polymicrobial infections:
Amoxicillin/clavulanate should not be used if:
For prolonged therapy, monitor liver enzymes and function
Diarrhea (common).
Allergy/rash, cytopenias.
Hepatotoxicity due to clavulinate is usually mild, liver failure is rare. EBV related rash (not allergy).
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Average serum half life: Adults: ~1 hour. Amoxicillin pharmacokinetics are not affected by clavulanic acid
Route of Elimination: Urine (amoxicillin 50% to 70% unchanged drug; clavulanic acid 25% to 40% unchanged drug)