Amoxicillin-Clavulanate - General Pediatric Dosing

  • Dosing based on amoxicillin component

  • Max daily dose of amoxicillin is 4g/day

  • Max daily dose of clavulanate is 12.5 mg/kg/day (preferred 10mg/kg/day)

Low dose: 40-50 mg/kg/DAY PO divided q8h

High dose: 80-90 mg/kg/DAY PO divided q12h

Term to 3 mo

4:1 30mg/kg/DAY PO divided q12h

Infant 3 mo to child less than 40kg

  • 4:1 25-45mg/kg/DAY PO divided q8h

  • 7:1 25-45mg/kg/DAY PO divided q12h

Child/Adolescent greater than or equal to 40kg or greater than or equal to 16 years old

  • 4:1 500mg PO q8-12h

  • 7:1 875mg PO q12h

Term to 3 mo:

4:1 30mg/kg/DAY PO divided q12h

Infant 3 mo to child less than 40kg

  • 7:1 45-60mg/kg/DAY PO divided q8h

  • 14:1 90mg/kg/DAY PO divided q8-12h (max 4g/day)

Child/Adolescent greater than or equal to 40kg or greater than or equal to 16 years old

  • 4:1 500mg PO q8h

  • 7:1 875mg PO q12h

Term to 3 mo

4:1 30mg/kg/DAY PO divided q12h

Infant 3 mo to child less than 40kg

  • 7:1 45-60mg/kg/DAY PO divided q8h

  • 14:1 90mg/kg/DAY PO divided q8h (max 4g/day)

Child/Adolescent greater than or equal to 40kg or greater than or equal to 16 years old

  • 4:1 500mg PO q8h

  • 7:1 875mg PO q12h

To achieve 90mg/kg/day at a 14:1 ratio, combine the following:

  • Amoxicillin/Clavulanic Acid 7:1 formulation 45mg/kg/DAY PO divided q8-12h

WITH

  • Amoxicillin 45mg/kg/DAY PO divided q8-12h

Example Order: Amox/Clav 200 mg (7:1 ratio) PO q8h WITH Amoxicillin 200 mg PO q8h for total 14:1 ratio