Amphotericin B deoxycholate

Restricted
C difficile risk
Low
Oral Bioavailability
N/A

Spectrum Of Activity

Dosing

Initial dose:
IV 0.25-0.5 mg/kg/DAY given as a single daily dose. Increase dose gradually to reach desired dose, usually in 0.25 mg/kg increments.Maintenance dose:
IV 0.25-1 mg/kg/DAY given as a single daily dose or 1-1.5 mg/kg/DOSE every 2 days. MAX daily dose: 1.5 mg/kg/DAY.

IV 1 mg/kg/DAY given as a single daily dose. Max 1.5mg/kg/DAY.

Contact pharmacy for more information regarding use in renal impairment.

General Information

Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity

Induction therapy for dimorphic fungii (cocci, blasto, histo)

Renal function, fluid status, serum electrolytes (K, Mg).

Liver enzymes, CBC with differential.

  • Infusion related symptoms: fever/rigors/N/V/headache

  • Electrolyte abnormalities - hypoKalemia and hypoMagnesemia, loss of bicarb

  • Nephrotoxicity ++

  • Anemia

  • Phlebitis

Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.

Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms.

Antimicrobial class: Antifungal - polyene

Average serum half life:

  • Premature neonates (GA: 27.4 ± 5 weeks): 14.8 hours (range: 5 to 82 hours)

  • Infants and Children (4 months to 14 years): 18.1 ± 6.6 hours (range: 11.9 to 40.3 hours)

Route of Elimination: Urine (2% to 5% unchanged); ~40% eliminated over 7-day period and may be detected in urine for up to 8 weeks after discontinued use