100-200mg/kg/DAY divided q6hMeningitis, CNS infections, endocarditis:
200-400mg/kg/DAY divided q4-6h. Max 12g/DAY.
0 - 2.0 kg2.0+ kgIV, IM 50mg/kg/dose q12hIV, IM 50mg/kg/dose q8h
0 - 2.0 kg2.0+ kg IV, IM 50mg/kg/dose q8h IV, IM 50mg/kg/dose q6h
PNA-days 0 - 7PNA-days 8+ IV 200-300mg/kg/day divided q8h.IV 300mg/kg/day divided q6h.
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.
Renal & liver function.
CBC with differential.
Allergy and rash
EBV related rash (not allergy)
Rare: cytopenias, +ve Coombs
Antimicrobial class: Aminopenicillin
Average serum half life:
Pediatrics: 1-1.8 hours
Anuric patients: 8-20 hours
Route of Elimination: