Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

100-200mg/kg/DAY divided q6hMeningitis, CNS infections, endocarditis:
200-400mg/kg/DAY divided q4-6h. Max 12g/DAY.

0 - 2.0 kg2.0+ kgIV, IM 50mg/kg/dose q12hIV, IM 50mg/kg/dose q8h

0 - 2.0 kg2.0+ kg IV, IM 50mg/kg/dose q8h IV, IM 50mg/kg/dose q6h

PNA-days 0 - 7PNA-days 8+ IV 200-300mg/kg/day divided q8h.IV 300mg/kg/day divided q6h.

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.

Renal & liver function.

CBC with differential.

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates

    • PNA 2-7days: 4 hours
    • PNA 8-14 days: 2.8 hours
    • PNA 15-30 days: 1.7 hour
  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours Excreted in bile