C difficile risk
Oral Bioavailability


IV, IM 50–100mg/kg/DAY divided q8h.
Max 2g/dose

IV, IM 100-150mg/kg/DAY divided q8h.
Max 2g/dose

IV, IM 50mg/kg/DAY divided q12h.

PNA-days 0 - 7PNA-days 8 - 28IV, IM 50mg/kg/DAY divided q12hIV, IM 75 mg/kg/DAY divided q8h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Skin and soft tissue infection (i.e. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias.

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Antimicrobial class: 1st Generation Cephalosporin

Average serum half life:

  • Neonates: 3-5 hours

  • Adults: 1.8 hours

Route of Elimination: excreted unchanged in urine